GUIDE TO SOME CONGENITAL, HERITABLE, and OTHER DISORDERS COMMON (AND NOT SO COMMON) TO GREAT DANES

GUIDE TO SOME CONGENITAL, HERITABLE, and OTHER DISORDERS COMMON (AND NOT SO COMMON) TO GREAT DANES

By Louise Feddema

There are many considerataions about getting a Great Dane, but some things to think about are Congenital, Genetic or those things which Great Danes have a predisposition to.

This list is here so that if and when you talk to breeders you can ask questions about your dog's family's health history.

Acral lick dermatitis: a skin disease caused by an animal licking a localized area excessively, specially on the legs and paws.
Bloat: a condition where a dog’s stomach produces excessive gas and enlarges severely enough to cause death without immediate treatment. Usually associated with gastric torsion. (See Gastric torsion.)
Calcinosis circumscripta: the development of lumps of hard calcium deposits in the skin.
Cardiomyopathy: a disease of weakened heart muscles.
Cataract: as in humans, a change in structure of the lens of the eye leading to cloudiness and usually to blindness.
Cerebellar hypoplasia: a condition where the cerebellum, a part of the brain, is poorly formed (too small or absent) and doesn’t function properly or at all.
Cervical disc disease: a degeneration or malformation of the cushioning discs between the spinal column bones (vertebrae) in the neck. (Also see Wobblers)
Cervical vertebral malformation or instability: a malformation of the vertebrae in the neck usually leading to nerve damage.
Color mutant alpaca: a condition where certain colored areas of a dog’s skin grow less or no fur.
Combined immunodeficiency: a severe combined deficiency of cell-mediated immunity (T-cell function) and low concentrations of serum immunoglobulins (IgA, IgG, and variably IgM). Affected puppies usually die from viral infections by 12-16 weeks of age.
Complement deficiency: a deficiency in serum concentrations of the third component of complement that impairs neutrophil function and causes recurrent infections.
Cystinuria: an abnormal excretion of a substance (cystine) in the urine.
Deafness: an inability to hear, due to many different causes. (Usually related to color) BAER Test
Demodicosis: a kind of skin disease (mange) caused by microscopic Demodex canis mites living within the skin layers and producing an immunodeficiency syndrome.
Dermoid cyst: a small growth composed of skin-like structures.
Distichiasis: abnormally growing eyelashes.
Ectropion: an abnormal rolling outward of the eyelids.
Entropion: an abnormal rolling inward of the eyelid.
Eversion of nictitating membrane: a condition where the third eyelid is protruding.
Gastric torsion: a condition where the stomach twists, thereby impeding input and output. (See Bloat.)
Glaucoma: abnormally high pressure in the eye. Test available
Hemeralopia: inability to see in daylight. Test available
Hip dysplasia: a developmental malformation or subluxation of the hip joints. Test available
Histiocytoma: a tumor composed of certain skin tissue cells (i.e., histiocytes).
Hygroma: a fluid-filled sac usually occurring on the elbows of large breed dogs such as the Great Dane.
Hypertrophic osteodystrophy: a condition of rapidly growing giant breeds where there is an abnormal inflammation of bones pain and development of excessive bony growths.
Hypothyroidism: a common endocrine disease where the body produces an abnormally low amount of thyroid hormones. An autoimmune destruction of the thyroid gland that affects more than 50 dog breeds. (See . Lymphocytic thyroiditis, Thyroiditis.)Test available
Iris heterochromia: a condition where one iris is a different color from the other or has more than one color to it.
Lymphocytic thyroiditis: an autoimmune disease causing inflammation and destruction of the thyroid gland, which becomes infiltrated with lymphocytes (white blood cells) and leads to hypothyroidism. This is the most common endocrine disease of the dog and has an inherited predisposition.
Metabolic bone disease: any of a number of diseases affecting the bones due to an abnormality of metabolism.
Microphthalmia: a condition where one or both eyes are too small.
Missing teeth
Mitral valve defects: a group of abnormalities of the mitral valve of the heart.
Multiple epiphyseal dysplasia: a condition where many of the long bones develop abnormally due to changes in the growth plates.
Muscular dystrophy: a congenital and often inherited form of generalized muscle dysfunction which causes signs such as poor growth, weakness, abnormal gait, difficulty eating and swallowing, and muscle atrophy. Affected animals have serious health problems and may die or be euthanatized.
Necrotizing myelopathy: a condition where the spinal cord gradually dies.
Osteochondritis dissecans—OCD: a specific form of inflammation of the cartilage of certain joints that causes arthritis.
Osteochondrosis: a group of developmental diseases resulting in abnormal formulation of joint cartilage. Commonly involves the shoulder, stifle, hock or elbow.
Osteosarcoma: a cancer arising from the cells of the bones.
Persistent right aortic arch: a developmental abnormality where one of the fetal blood vessels near the heart does not atrophy, as it should.
Pododermatitis: a skin infection of the paws.
Progressive ataxia: a condition where the animal’s sense of coordination deteriorates. Test available
Progressive retinal atrophy: a disease where the retina slowly deteriorates, producing night blindness. Test available
Retinal dysplasia: a condition where the retina is malformed. Test available
Spondylolisthesis (Wobbler’s syndrome): a condition where the vertebrae of the neck slip out of joint and are malformed causing progressive in coordination of the rear legs.
Thyroiditis: an autoimmune inflammatory disease of the thyroid gland. Test available
Von Willebrand’s disease: a type of bleeding disorder caused by defective blood platelet function. An autosomal trait affecting both sexes. Test Available
Wobbler’s syndrome (see Spondylolisthesis)

Disclaimer: This list is probably not inclusive of all the diseases Great Danes are "prone to", there are many (not listed here) that all dogs are potential candidates for. There are also some that I have missed. Some of the diseases or conditions are very rare, some are more common. Some are life threatening, some are fairly easily treated. There is no priority (other than alphabetical) for the conditions listed. I am not a vet or anything like one -- just a Dane owner.

Return Home